史向阳

个人简介

史向阳，博士生导师，校特聘教授。1998年于中科院感光化学研究所获博士学位。2008年回国前，在美国密歇根大学历任博士后研究员、第二级副研究员、研究员和研究助理教授。主要学术兼职包括：葡萄牙马德拉大学“邀请纳米技术主任”；WIREs Nanomed. Nanobiotechnol.期刊副主编；Bioconjugate Chem.、Nanomedicine、Pharmaceutics等期刊编委。北京生理科学会常务理事、上海市生物物理学会理事。

研究方向

基于树状大分子及其它类高分子的纳米医学、生物材料研究，主攻方向为肿瘤和炎症（包括肺炎、关节炎、脑卒中、帕金森等）诊疗和预防的纳米药物基础及应用基础研究。

荣誉及获奖情况

2008/2013年获上海高校特聘教授（东方学者）及跟踪计划，2011年教育部新世纪优秀人才，2018年上海市领军人才，2019年上海市优秀学术带头人。2014年获第五届中国侨界贡献奖创新人才奖；2016年获华夏医学科技奖二等奖；2017年获上海市科技进步奖一等奖；2018年获上海市自然科学奖一等奖。2019-2021爱思维尔中国高被引学者，2019 年英国皇家化学会Top 1% 高被引中国作者。

主持与承担主要项目情况

主持项目包括科技部国家重点研发计划国合专项1项；国家自然基金重点国合项目1项、中德中心项目2项、面上项目3项、一般国际交流项目1项及上海市科委/教委项目多项。

发表论著情况

发表SCI收录期刊论文457篇，论文引用超过23000次，H-index为79。

主要学术论文（2017-2022代表作）

1.     Tingting Xiao^#, Jianzhi Zhu^#, Liang Jia^#, Hailong Che, Jie Liu, N. Amy Yewdall, J. Deckers, and Jan C. M. van Hest*, Xiangyang Shi*. Injectable alginate hydrogels for synergistic tumor combination therapy via repolarization of TAMs. J. Controlled Release2022, 348, 239-249.

2.     Jin Li, Liang Chen, Changsheng Li, Yu Fan, Mengsi Zhan, Serge Mignani, Jean-Pierre Majoral, Mingwu Shen*, Xiangyang Shi*. Phosphorus Dendron Nanomicelles as a Platform for Combination Anti-Inflammatory and Antioxidative Therapy of Acute Lung Injury. Theranostics2022, 12(7), 3407-3419.

3.     Changchang Zhang^#, Wenzhi Tu^#, Xuming Chen, Bing Xu, Xin Li, Chaolei Hu, Mingwu Shen, Shaoli Song, Chunjuan Jiang, Shengyu Yao, Andrij Pich*, Yong Liu*, Xiangyang Shi*. Intelligent design of polymer nanogels for full-process sensitized radiotherapy and dual-mode computed tomography/magnetic resonance imaging of tumors. Theranostics2022, 12(7): 3420-3437.

4.     Zhiqiang Wang, Yunqi Guo, Yu Fan, Jingwen Chen, Han Wang, Mingwu Shen, Xiangyang Shi*. Metal-Phenolic Network-Coated Dendrimer-Drug Conjugates for Tumor MR Imaging and Chemo/Chemodynamic Therapy via Amplification of Endoplasmic Reticulum Stress. Adv. Mater.2022, 34, 2107009.

5.     Yao Xu, Yunqi Guo, Changchang Zhang, Mengsi Zhan, Liang Jia, Shaoli Song, Chunjuan Jiang, Mingwu Shen, Xiangyang Shi*. Fibronectin-Coated Metal-Phenolic Networks as a Platform for Cooperative Tumor Chemo/Chemodynamic/Immune Therapy via Enhanced Ferroptosis-Mediated Immunogenic Cell Death. ACS Nano2022, 16, 984-996.

6.     Yingchao Hao, Yue Gao, Yu Fan, Changchang Zhang, Mengsi Zhan, Xueyan Cao, Xiangyang Shi*, Rui Guo*. A Tumor Microenvironment-Responsive Poly(amidoamine) Dendrimer Nanoplatform for Hypoxia-Responsive Chemo/Chemodynamic Therapy. J. Nanobiotechnol.2022, 20, 43.

7.     Jingchao Li^#, Xiangrong Yu^#, Xiangyang Shi,* Mingwu Shen*. Cancer nanomedicine based on polyethylenimine-mediated multifunctional nanosystems. Prog. Mater. Sci.2022, 124, 100871.

8.     Wei Hu, Tingting Xiao, Du Li, Yu Fan, Lingxi Xing*, Xipeng Wang, Yulin Li*, Xiangyang Shi*, Mingwu Shen*. Intelligent Molybdenum Disulfide Complexes as a Platform for Cooperative Imaging-Guided Tri-mode Chemo-Photothermo-Immunotherapy. Adv. Sci.2021, 8, 2100165.

9.     Xin Li, Haitao Sun, Helin Li, Chaolei Hu, Yu Luo*, Xiangyang Shi* and Andrij Pich*. Multi-responsive biodegradable cationic nanogels for highly efficient treatment of tumors. Adv. Funct. Mater.2021, 31, 2100227.

10.  Xin Li^#, Helin Li^#, Changchang Zhang, Andrij Pich*, Lingxi Xing*, and Xiangyang Shi*. Intelligent nanogels with self-adaptive responsiveness for improved tumor drug delivery and augmented chemotherapy. Bioact. Mater. 2021, 6, 3473-3484.

11.  Xin Li, Zhijun Ouyang, Helin Li, Chaolei Hu, Pabitra Saha, Lingxi Xing*, Xiangyang Shi*, Andrij Pich*. Dendrimer-decorated nanogels: Efficient nanocarriers for biodistribution in vivo and chemotherapy of ovarian carcinoma. Bioact. Mater. 2021, 6, 3244-3253.

12.  Dan Li, Lizhou Lin, Yu Fan, Long Liu, Mingwu Shen, Rong Wu, Lianfang Du*, Xiangyang Shi*. Ultrasound-Enhanced Fluorescence Imaging and Chemotherapy of Multidrug-Resistant Tumors Using Multifunctional Dendrimer/Carbon Dot Nanohybrids. Bioact. Mater.2021, 6, 729-739.

13.  Tingting Xiao, Meijuan He, Fang Xu, Yu Fan, Bingyang Jia, Mingwu Shen, Han Wang* and Xiangyang Shi*. Macrophage Membrane-Camouflaged Responsive Polymer Nanogels Enable Magnetic Resonance Imaging-Guided Chemotherapy/Chemodynamic Therapy of Orthotopic Glioma. ACS Nano2021, 15, 20377–20390.

14.  Liang Jia, Xin Li, Hui Liu, Jindong Xia, Xiangyang Shi*, Mingwu Shen*. Ultrasound-enhanced precision tumor theranostics using cell membrane-coated and pH-responsive nanoclusters assembled from ultrasmall iron oxide nanoparticles. Nano Today2021, 36, 101022.

15.  Yunchao Xiao^#, Yu Fan^#, Wenzhi Tu, Shiyi Lu, Yupei Ma, Yuesheng Ning, Yong Liu*, and Xiangyang Shi*. Multifunctional PLGA Microfibrous Rings Enable MR Imaging-Guided Tumor Chemotherapy and Metastasis Inhibition Through Prevention of Circulating Tumor Cell Shedding. Nano Today2021, 38, 101123.

16.  Cong Song, Zhijun Ouyang, Yue Gao, Honghua Guo, Shunjuan Wang, Dayuan Wang, Jindong Xia, Mingwu Shen,* Xiangyang Shi*. Modular Design of Multifunctional Core-Shell Tecto Dendrimers Complexed with Copper(II) for MR Imaging-Guided Chemodynamic Therapy of Orthotopic Glioma. Nano Today2021, 41, 101325.

17.  Chao Yang, Yue Gao, Yu Fan, Liu Cao, Jin Li, Yulong Ge, Wenzhi Tu, Yong Liu, Xueyan Cao, and Xiangyang Shi*. Dual-mode endogenous and exogenous sensitization of tumor radiotherapy through antifouling dendrimer-entrapped gold nanoparticles. Theranostics2021, 11(4), 1721-1731.

18.  Zhijuan Xiong, Yue Wang, Wei Zhu, Zhijun Ouyang, Yu Zhu, Mingwu Shen, Jindong Xia*, Xiangyang Shi*. A Dual-Responsive Platform Based on Antifouling Dendrimer-CuS Nanohybrids for Enhanced Tumor Delivery and Combination Therapy. Small Methods2021, 5, 2100204.

19.  Tingting Xiao, Wei Hu, Yu Fan, Mingwu Shen, Xiangyang Shi*. Macrophage-Mediated Tumor Homing of Hyaluronic Acid Nanogels Loaded with Polypyrrole and Anticancer Drug for Targeted Combinational Photothermo-Chemotherapy. Theranostics2021, 11(14), 7057-7071. doi: 10.7150/thno.60427.

20.  Jin Li, Liang Chen, Xiaoying Xu, Yu Fan, Xue Xue, Mingwu Shen*, Xiangyang Shi*. Targeted Combination of Antioxidative and Anti-Inflammatory Therapy of Rheumatoid Arthritis Using Multifunctional Dendrimer-Entrapped Gold Nanoparticles as a Platform. Small2020, 16, 2005661.

21.  Jianzhi Zhu^#, Tingting Xiao^#, Yuxin Shi, Hailong Che, Xiangyang Shi* and Jan C. M. Hest*. Surface charge switchable nanoclusters for MRI-guided synergistic photodynamic therapy. ACS Nano2020, 14, 11225-11237.

22.  Yu Fan, Lizhou Lin, Fangfang Yin, Yu Zhu, Han Wang, Lianfang Du, Serge Mignani, Jean-Pierre Majoral*, Xiangyang Shi*. Phosphorus Dendrimer-Based Copper(II) Complexes Enable Ultrasound-Enhanced Tumor Theranostics. Nano Today2020, 33, 100899.

23.  Cong Song, Mingwu Shen, João Rodrigues, Serge Mignani, Jean-Pierre Majoral, Xiangyang Shi*.Superstructured poly(amidoamine) dendrimer-based nanoconstructs as platforms for cancer nanomedicine: a concise review. Coord. Chem. Rev.2020, 421, 213463.

24.  Lingxi Xing^#, Xin Li^#, Zehua Xing^#, Fan Li, Mingwu Shen, Hong Wang*, Xiangyang Shi*, Lianfang Du*. Silica/Gold Nanoplatform combined with a Thermosensitive Gel for Imaging-guided Interventional Therapy in PDX of Pancreatic Cancer. Chem. Eng. J.2020, 382, 122949.

25.  Fang Xu^#, Jianzhi Zhu^#, Lizhou Lin^#, Changchang Zhang, Wenjie Sun, Yu Fan, Fangfang Yin, Jan C. M. van Hest, Han Wang, Lianfang Du* and Xiangyang Shi*. Redox-responsive PVCL nanogels loaded with MnO₂ nanoparticles and doxorubicin for imaging-guided and UTMD-promoted chemotherapy of tumors. Theranostics2020, 10(10), 4349-4358.

26.  Yu Fan^#, Wenzhi Tu^#, Mingwu Shen, Xuming Chen, Yuesheng Ning, Junjun Li, Tingfeng Chen, Han Wang, Fangfang Yin, Yong Liu*, Xiangyang Shi*. Targeted Tumor Hypoxia Dual Mode CT/MR Imaging and Enhanced Radiation Therapy Using Dendrimer-Based Nanosensitizers. Adv. Funct. Mater.2020, 30, 1909285.

27.  Xin Li^#, Shiyi Lu^#, Zuogang Xiong, Yong Hu, Dan Ma, Wenqi Lou, Chen Peng*, Mingwu Shen*, Xiangyang Shi*. Light-Addressable Nanoclusters of Ultrasmall Iron Oxide Nanoparticles for Enhanced and Dynamic Magnetic Resonance Imaging of Arthritis. Adv. Sci.2019, 6, 1901800.

28.  Chao Cai, Xin Li, Yue Wang, Mengxue Liu, Xiangyang Shi*, Jindong Xia*, Mingwu Shen*. Polydopamine-Coated Gold Core/Hollow Mesoporous Silica Shell Particles as a Nanoplatform for Multimode Imaging and Photothermal Therapy of Tumors. Chem. Eng. J.2019, 362, 842-850.

29.  Yu Fan, Jiulong Zhang, Menghan Shi, Dan Li, Chunhua Lu, Xueyan Cao, Chen Peng*, Serge Mignani*, Jean-Pierre Majoral*, Xiangyang Shi*. PAMAM Dendrimer-Coordinated Copper(II) Complexes as a Theranostic Nanoplatform for Radiotherapy-Enhanced MR Imaging and Chemotherapy of Tumors and Tumor Metastasis. Nano Lett.2019, 19, 1216−1226.

30.  Jianzhi Zhu^#, Zhicong Li^#, Changchang Zhang, Lizhou Lin, Shoupeng Cao, Hailong Che, Xiangyang Shi*, Han Wang*, Jan C. M. van Hest*. Single enzyme loaded nanoparticles for combinational ultrasound-guided focused ultrasound ablation and hypoxia-relieved chemotherapy. Theranostics2019, 9(26), 8048-8060.

31.  Shiyi Lu, Xin Li, Jiulong Zhang, Chen Peng,* Mingwu Shen,* and Xiangyang Shi*. Dendrimer-Stabilized Gold Nanoflowers Embedded with Ultrasmall Iron Oxide Nanoparticles for Multimode Imaging-Guided Combination Therapy of Tumors. Adv. Sci.2018, 5, 1801612.

32.  Yong Hu, Serge Mignani, Jean-Pierre Majoral, Mingwu Shen*, and Xiangyang Shi*. Construction of iron oxide nanoparticle-based hybrid platforms for tumor imaging and therapy. Chem. Soc. Rev.2018, 47, 1874-1900.

33.  Lizhou Lin^#, Yu Fan^#, Feng Gao, Lifang Jin, Dan Li, Wenjie Sun,Fan Li, Peng Qin, Qiusheng Shi*, Xiangyang Shi*, Lianfang Du*.UTMD-Promoted Co-Delivery of Gemcitabine and miR-21 Inhibitor by Dendrimer-Entrapped Gold Nanoparticles for Pancreatic Cancer Therapy. Theranostics2018, 8(7), 1923-1939.

34.  Yu Fan^#, Wenjie Sun^#, Xiangyang Shi*. Design and Biomedical Applications of Poly(amidoamine) Dendrimer-Based Hybrid Nanoarchitectures. Small Methods2017, 1(12), 1700224.

其他信息

国际交流与合作：美国密歇根大学、法国国家科研中心配合物化学实验室、法国巴黎大学、法国波尔多大学、德国亚琛工业大学/莱布尼茨聚合物研究所、荷兰埃因霍温理工大学、葡萄牙马德拉大学、匈牙利徳布勒森大学、日本大阪大学、韩国檀国大学、以色列巴伊兰大学、波兰罗茨大学、土耳其海峡大学、白俄罗斯国家科学院生物物理与细胞工程研究所。

主讲课程：

博士研究生课程：先进纳米医学和博士生Seminar；本科生课程：纳米医学。

博士后和研究生招生信息：

欢迎感兴趣的具有化学、化工、生物医学、材料、纺织等相关研究背景的博士生申请博士后研究职位，同时欢迎感兴趣的具有相同背景的本科生和硕士生报考加入本课题组。

联系方式

E-mail: xshi@dhu.edu.cn