娄向新bwin体育,副研究员,硕士生导师。2007年华东师范大学生理学博士。德国洪堡大学Charite医学院(2008-2010年)和日本京都大学医学院(2010-2012年)博士后,2012年东华大学海外引进优秀留学归国人员。自2002年起围绕干细胞开展了一系列具有国际影响力的研究工作,日本留学期间参与了日本iPS细胞国家研究发展计划(京都大学iPS细胞研究获得2012年诺尔医学或生理学奖)。在干细胞和神经科学领域国际主流学术刊上发表学术论文40多篇。现为国际干细胞学会会员、国际耳科学学会会员、中国神经科学学会会员,中国化学学会会员,是国际期刊Journal of Stem Cells Research, Reviews & Reports和Archives of Stem Cell Research编委。
主要研究方向
1. 诱导型多能干细胞(iPS细胞)的定向分化
2. 干细胞与骨、神经组织再生
3. 哺乳动物内耳发育与毛细胞的再生
主要研究项目
1. 上海市自然科学基金面上项目,20ZR1401200,模拟听觉柯蒂氏器类器官诱导毛细胞三维再生的机制研究,2020/07-2023/06,主持
2. 上海中医药大学附属岳阳中西医结合医院横向课题,105190308,淫羊藿总黄酮经BMP7通路调节棕/白色脂肪比例影响ApoE基因敲除小鼠动脉粥样硬化病理环境的实验研究,2019/06-2022/11,主持
3. 上海楚豫生物科技有限公司横向课题,105180731,三维纳米纤维支架在骨组织的修复与再生中的应用,2018/11-2022/11,主持
4. 中央高校科研专项基金重点项目,16D110520,负载骨细胞外基质的纳米纤维支架的制备及其对人源iPS细胞的成骨作用研究,2016/01-2018/12,主持
5. 上海市自然科学基金面上项目,15ZR1400500,仿生复合纳米纤维对人源iPS-MSCs的成骨诱导作用及其机制研究,2015/01-2017/12,主持
6. 国家自然科学基金项目,31570969,仿生超细“中性纤维”的设计制备与修复肌腱缺损功效评价,2016/01-2019/12,参与
7. 上海市科委基础研究重点项目,14JC1490100,用于原位骨组织工程的多功能仿生纳米纤维支架的构建,2014/09-2017/08,参与
8. 中央高校科研专项基金项目,2232013D3-13,壳聚糖纳米纤维对iPS细胞诱导及分化的研究,2013/01-2015/12,主持
代表性论文(*为通讯作者)
1. Yunliang Wu, Lei Zhou, Yuexia Li, Xiangxin Lou*. Osteoblast-derived extracellular matrix coated PLLA/silk fibroin composite nanofibers promote osteogenic differentiation of bone mesenchymal stem cells. J Biomed Mater Res. 2021, 1-10.
2. Siying Zhong, Xufeng He, Yuexia Li, Xiangxin Lou*. Conditioned medium enhances osteogenic differentiation of iPS cell-derived mesenchymal stem cells. Tissue Engineering and Regenerative Medicine, 2019, 16(2):141-150.
3. Yuexia Li, Yunliang Wu, Hongmei Liu, Xiangxin Lou*. Influence of DAPT on neomycin ototoxicity in cultured organ of Corti explants. Neuro Report, 2018, 29(12):1011-1016.
4. YunLiang Wu, Chunping Qin, Xianliu Wang, Xiangxin Lou*. Enhanced proliferation of BMSCs supported by nanofibrous scaffold containing osteoblasts-derived extracellular matrix. Journal of Controlled Release, 2017, 259: e184-185.
5. YunLiang Wu, Chunping Qin, Xianliu Wang, Xiangxin Lou*. Nanofibrous Scaffold Containing Osteoblast-derived Extracellular Matrix for the Proliferation of BMSCs. Journal of Donghua University (English Edition),2017, (06): 756-760.
6. Jing Xie, Chen Peng, Qinghua Zhao, Xianliu Wang, Huihua Yuan, Liangliang Yang, Kai Li, Xiangxin Lou*, Yanzhong Zhang*. Osteogenic differentiation and bone regeneration of iPSC-MSCs supported by a biomimetic nanofibrous scaffold. Acta Biomaterialia, 2016, 29:365-379.
7. Xiangxin Lou*. Induced pluripotent stem cells as a new strategy for osteogenesis and bone regeneration. Stem Cell Rev and Rep, 2015, 11:645-651.
8. Xiangxin Lou*, Huihua Yuan, Jing Xie, Xianliu Wang, Liangliang Yang, Yanzhong Zhang. Growth factors have a protective effect on neomycin-induced hair cell loss. Cell Biology International, 2015, 39: 65-73.
9. Xiangxin Lou, Siying Zhong, Jing Xie, Yanzhong Zhang. Osteoblast conditioned medium stimulates osteogenic differentiation of iPS cell-derived mesenchymal stem cells. Tissue Engineering Part A,2015, 21(S1): S-211.
10. Dongshu Du,Xiangxin Lou*. Generation of induced pluripotent stem cells from neonatal mouse cochlear cells, Differentiation, 2014, 87: 127-133.
11. Xiangxin Lou, Youyi Dong, Jing Xie, Xianliu Wang, Liangliang Yang, Masaaki Tokuda, Yanzhong Zhang. Comparing the cultivated cochlear cells derived from neonatal and adult mouse. Journal of translational medicine, 2014, 12(1): 150.
12. Xiangxin Lou*, Jing Xie, Xianliu Wang, Liangliang Yang, Yanzhong Zhang. Comparison of sphere-forming capabilities of the cochlear stem cells derived from apical, middle and basal turns of murine organ of Corti. Neuroscience Letters, 2014, 579: 1-6.
承担教学
1. 细胞工程
2. 组织工程与再生医学
E-mail:xiangxin@dhu.edu.cn
上海市松江区人民北路2999号4号化工学院楼3121室,201620